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Effect of Carvedilol, Ivabradine or Their Combination on Exercise Capacity in Patients with Heart Failure (The CARVIVA HF Trial)

Effect of Carvedilol, Ivabradine or Their Combination on Exercise Capacity in Patients with Heart Failure (The CARVIVA HF Trial)

Heart failure (HF) constitutes a major public health problem. It has a substantial clinical, social, and economic burden, notably due to significant functional limitations and the reduced quality of life of patients.

Quality of Life Improvement in Older Patients with Heart Failure Initiated on Ivabradine: Results from the UK Multi-Centre Live: Life Prospective Cohort Study

Quality of Life Improvement in Older Patients with Heart Failure Initiated on Ivabradine: Results from the UK Multi-Centre Live: Life Prospective Cohort Study

The Cardiovascular Health Study estimated CHF incidence as 19.3 per 1000 person-years in those aged >65 years.

Duration of chronic heart failure affects outcomes with preserved effects of heart rate reduction with Ivabradine: findings from SHIFT

Duration of chronic heart failure affects outcomes with preserved effects of heart rate reduction with Ivabradine: findings from SHIFT

Chronic heart failure (CHF) is a clinical syndrome frequently accompanied by a high load of co-morbidities and characterized by poor outcomes, despite the provision of optimal medical guideline-directed treatments.

Ivabradine and Outcomes in Chronic Heart Failure (SHIFT): A Randomised Placebo-Controlled Study

Ivabradine and Outcomes in Chronic Heart Failure (SHIFT): A Randomised Placebo-Controlled Study

Chronic heart failure affects roughly 2–3% of the population in many industrialised countries.

Ivabradine in Heart Failure the Representativeness of SHIFT (Systolic Heart Failure Treatment with the IF Inhibitor Ivabradine Trial) in a Broad Population of Patients with Chronic Heart Failure

Ivabradine in Heart Failure the Representativeness of SHIFT (Systolic Heart Failure Treatment with the IF Inhibitor Ivabradine Trial) in a Broad Population of Patients with Chronic Heart Failure

An elevated resting heart rate (HR) is a known risk marker and likely risk factor for adverse outcomes in patients with heart failure (HF).

Efficacy and Safety of Ivabradine in Patients with Chronic Systolic Heart Failure and Diabetes: An Analysis from the SHIFT Trial

Efficacy and Safety of Ivabradine in Patients with Chronic Systolic Heart Failure and Diabetes: An Analysis from the SHIFT Trial

Diabetes mellitus and chronic heart failure (HF), both common conditions increasing in prevalence as the general population ages, are significant burdens to public health.

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