Single-Pill Combinations: Revolutionizing Hypertension Control

Hypertension remains a leading cause of cardiovascular morbidity and mortality worldwide, with suboptimal control and poor medication adherence posing significant challenges, particularly for cardiometabolic patients in 2025. Single-pill combinations (SPCs), which integrate multiple antihypertensive drugs into a single dose, have emerged as a transformative approach to address these issues. By simplifying treatment regimens, SPCs significantly improve patient adherence compared to multi-pill regimens, which often lead to missed doses and therapeutic failure.