This case report details an extremely rare disease called drug-induced immune hemolytic anemia (DIIHA) that developed in a 52-year-old man once he started using the drug dapagliflozin (Farxiga), a drug often prescribed for diabetes. The report speculates that this could be the first to link this particular drug to this unusual disorder. DIIHA is a dangerous side effect wherein the immune system abnormally reacts against and destroys red blood cells upon exposure to a drug. While extremely uncommon, affecting 1-2 people per million individuals per year, it is life-threatening unless treated.
This study from the CORDIOPREV trial explored how small genetic molecules known as microRNAs (miRNAs) could assist doctors in selecting the most suitable diet for patients with both heart disease and Type 2 diabetes, potentially aiding in the reversal of their diabetes.
A 67-year-old hypertensive diabetic with hyperlipidemia who presented with chest pain, progressive exertional dyspnea, orthopnea, and swelling in both the lower extremities. Initial investigation such as an electrocardiogram and cardiac catheterization excluded acute ischemia but documented nonobstructive coronary disease. Transthoracic echocardiography demonstrated left ventricular hypertrophy, severe systolic dysfunction, and increased filling pressures, suspicious for cardiac amyloidosis.
This research investigated whether intravenous dexamethasone added to an interscalene block (a standard method of pain control for shoulder surgery) would be better than the block alone for controlling pain after rotator cuff repair surgery. Rotator cuff surgery is likely to produce intense postoperative pain, and good methods of alleviating this pain are needed. Interscalene blocks are good for the relief of pain for a limited time, but they have rebound pain, and their action is not prolonged and needs to be supplemented.
The study explores the action of amlodipine, a drug used commonly to treat hypertension, on lung cancer cells. Lung cancer is one of the leading causes of cancer-related deaths globally, and the currently available treatment strategies like chemotherapy are associated with critical side effects and diminish efficacy over time due to the emergence of chemoresistance.
