In most countries, especially in South Asia, the burden of diabetes and obesity has increased in past few decades. Anjana RM, presented a session at IDF World Diabetes Congress 2025 from 7th-10th April 2025 in Bangkok. In South Asians, type 2 diabetes tends to develop at least 10 years earlier and at significantly lower BMI levels compared to White Europeans.
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with rising global prevalence and limited curative treatments. Through genetic integration using Mendelian randomization (MR) and genome-wide association studies (GWAS), 42 protein-coding genes were identified as being significantly associated with T2DM. Of these, six genes – CLSTN1, KCNJ11, MLX, DLD, RELA, and ULK1—shared common causal variants with the disease, indicating potential as drug targets.
Recent prescription trends for novel heart failure medications were analyzed at a major Kansas City safety net hospital, focusing on the utilization patterns of sacubitril/valsartan and SGLT2 inhibitors in underserved populations. The study examined prescription data from October 2021 to October 2022, involving 769 patients receiving sacubitril/valsartan and 2,287 patients prescribed SGLT2 inhibitors.
Heart failure (HF) is a growing problem worldwide, causing high healthcare costs and lower quality of life. While medications are key, lifestyle changes like diet, exercise, and managing weight, smoking, and stress are also important. These changes, along with medicines, can improve how well patients do, reduce hospital visits, and help the medicines work better.
The article is a study of cardiovascular health, looking into how a given disease or therapy affects cardiovascular health. Researchers conducted a study to look at how various factors, including drugs, lifestyle, or medical therapies, affect heart disease, heart attack, or cardiovascular function as a whole. The study tracked a cohort of cardiovascular patients over a period of time to see how their condition progressed and if the treatments were working.
