Association of Cumulative Systolic Blood Pressure with Long-Term Risk of Cardiovascular Disease and Healthy Longevity

Individuals with similar contemporary SBP may be at different long-term risk for CVD due to differences in their cumulative exposure to SBP.

Cardiac pacing in severe recurrent reflex syncope and tilt-induced asystole

The study suggest the utility of tilt testing as a method for selecting pacemaker candidates.

Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women

Natural premature menopause may represent a risk signal for latent genomic instability and predilection to develop CHIP and CHIP-associated cardiovascular disease.

Effects of n-3 Fatty Acid Supplements in Elderly Patients after Myocardial Infarction: A Randomized Controlled Trial

First study to show that a genetic risk score remains an independent predictor of ischemic stroke in subjects who are older and have established cardiometabolic disease.

A Plasma Lipid Signature Predicts Incident Coronary Artery Disease

First study to show that lipidomic measurements can be used to achieve significant improvements in risk prediction of CAD in a large cohort with long-term follow-up

Novel Antisense Therapy Targeting microRNA-132 in Patients with Heart Failure: Results of a First-in-human Phase 1b Randomized, Double-blind, Placebo-controlled Study

This study is the first clinical trial of an antisense drug CDR132L in HF patients.