The 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia represents a major update in lipid management, integrating contemporary evidence to optimize prevention of atherosclerotic cardiovascular disease (ASCVD). The guideline provides a comprehensive, life-course approach to the evaluation, treatment, and monitoring of dyslipidemias, encompassing both primary and secondary prevention strategies.
Psoriatic arthritis (PsA) is a chronic immune-mediated inflammatory disease characterized by joint inflammation, structural damage, and associated skin manifestations of psoriasis. Despite the availability of several biologic and targeted therapies, many patients continue to experience persistent disease activity or treatment intolerance, highlighting the need for additional therapeutic options. Deucravacitinib (Sotyktu), an oral selective tyrosine kinase 2 (TYK2) inhibitor developed by Bristol Myers Squibb, has now received approval from the U.S. Food and Drug Administration for the treatment of adults with active psoriatic arthritis. This approval represents the first TYK2 inhibitor authorized for this indication and introduces a novel mechanism targeting intracellular cytokine signaling pathways involved in immune-mediated inflammation.
Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disorder characterized by progressive muscle degeneration caused by mutations in the dystrophin gene. Z-rostudirsen (DYNE-251) is an investigational exon-51–skipping therapy designed to restore the production of functional dystrophin by enabling targeted delivery of a phosphorodiamidate morpholino oligomer to muscle tissue. Dyne Therapeutics recently reported new cardiopulmonary and long-term clinical results from the Phase 1/2 DELIVER trial evaluating this therapy in individuals with DMD amenable to exon 51 skipping.
Diabetes mellitus is a chronic metabolic disorder with high global prevalence and considerable risk of long-term complications if glucose levels remain uncontrolled. Mobile health (mHealth) interventions—leveraging smartphones, SMS messaging, and telehealth technologies—offer scalable tools for diabetes self-management, patient engagement, and clinical monitoring. This systematic review and meta-analysis aimed to comprehensively evaluate both the clinical efficacy and cost-effectiveness of mHealth interventions in diabetes care.
Glomerular hyperfiltration at the single-nephron level often precedes detectable whole-kidney GFR decline in type 2 diabetes (T2D). Renal functional reserve (RFR), measured as the postprandial GFR increase, may unmask this hidden hyperfiltration. Sodium-glucose co-transporter-2 inhibitors (SGLT2i) like empagliflozin reduce intraglomerular pressure via tubuloglomerular feedback, often causing an initial GFR dip. We hypothesized that lower baseline postprandial RFR predicts greater empagliflozin-induced GFR reduction, but not responses to dipeptidyl-peptidase-4 inhibitor (linagliptin) or sulfonylurea.
