Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women

Natural premature menopause may represent a risk signal for latent genomic instability and predilection to develop CHIP and CHIP-associated cardiovascular disease.

Effects of n-3 Fatty Acid Supplements in Elderly Patients after Myocardial Infarction: A Randomized Controlled Trial

First study to show that a genetic risk score remains an independent predictor of ischemic stroke in subjects who are older and have established cardiometabolic disease.

A Plasma Lipid Signature Predicts Incident Coronary Artery Disease

First study to show that lipidomic measurements can be used to achieve significant improvements in risk prediction of CAD in a large cohort with long-term follow-up

Novel Antisense Therapy Targeting microRNA-132 in Patients with Heart Failure: Results of a First-in-human Phase 1b Randomized, Double-blind, Placebo-controlled Study

This study is the first clinical trial of an antisense drug CDR132L in HF patients.

Causal Effect Between Total Cholesterol and HDL Cholesterol as Risk Factors for Chronic Kidney Disease: A Mendelian Randomization Study

The MR study indicate causal effects between TC, HDL-C and CKD. Decreased TC and elevated HDL-C may reduce the incidence of CKD but need to be further confirmed by using a genetic and environmental approach.