How Changes in Insulin Resistance Influence Heart Disease Risk

How Changes in Insulin Resistance Influence Heart Disease Risk

The researchers set out to find out how over-time variation in insulin resistance (IR) may influence the development of cardiovascular disease (CVD). Researchers studied data from a large Chinese health survey and used two key markers to measure IR: the triglyceride-glucose (TyG) index and the TyG-BMI index (which combines TyG with body mass index).

Comparative Analysis of SGLT2 Inhibitors and Their Influence on Nighttime Voiding

Comparative Analysis of SGLT2 Inhibitors and Their Influence on Nighttime Voiding

This cross-sectional study by Sato et al. investigates the impact of Sodium-Glucose Co-Transporter-2 (SGLT2) inhibitors on nocturnal polyuria in type 2 diabetic patients, in particular on a comparison between the short-acting inhibitor tofogliflozin and other SGLT2 inhibitors. The sample was 142 patients, divided into two groups: one that received SGLT2 inhibitors and one that received none.

Early Blood Sugar Issues May Lead to Heart Valve Disease

Early Blood Sugar Issues May Lead to Heart Valve Disease

The study explores the correlation between blood glucose level and early signs of a cardiac disease called aortic valve calcification (AVC) in middle-aged people. AVC is a disease in which calcium deposits in the aortic valve harden the valve, and it may eventually lead to aortic stenosis (AS). Without treatment, the disease is hazardous, as it affects the blood flow from the heart.

Preserving Beta Cells: A Novel Approach to Type 2 Diabetes Treatment

Preserving Beta Cells: A Novel Approach to Type 2 Diabetes Treatment

This research analyzes a new way of protecting insulin-secreting beta cells against the pathogenic action of glucolipotoxicity caused by excessive blood glucose and lipids. Glucolipotoxicity is one of the chief causative mechanisms of Type 2 Diabetes (T2D), a global disease that targets millions of individuals.