Recent research has highlighted potential risks associated with treating type 2 diabetes, especially when certain medications are used together. For people whose blood sugar remains high even after taking metformin (a common first-line diabetes drug), doctors sometimes add other medications like pioglitazone or insulin. However, the study found that these combinations may significantly increase the risk of developing ischemic heart disease (IHD), a condition where the heart doesn’t get enough oxygen due to blocked arteries.
The risk of heart disease was particularly high when both pioglitazone and insulin were added to metformin. This raises concerns because heart disease is already a leading complication for people with diabetes. Using these drugs together might amplify the danger, potentially leading to serious problems like chest pain, heart attacks, or other cardiovascular issues.
Given these findings, healthcare providers are encouraged to explore safer treatment options for people with uncontrolled diabetes. There are other medications and approaches that may help manage blood sugar without posing such high risks to heart health.
This research serves as a reminder that diabetes management is not just about controlling blood sugar but also about protecting overall health. Patients should work closely with their doctors to understand the risks and benefits of their treatment plans and to make informed decisions about their care.
Source: sciencedirect.com/science/article/abs/pii/S1056872724002241
